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Methotrexate Koçak (Brand name: Methotrexate)

  • $1.27
  • Brand name: Methotrexate
  • Availability: In Stock
  • Active Ingredient methotrexate
Methotrexate Koçak is an antimetabolite used to treat certain types of cancer.
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2.5 mg
Product name Per Pill Per Pack  
30 pills $1.95 $58.50
60 pills $1.58 $117.00 $94.66
90 pills $1.45 $175.50 $130.82
120 pills $1.39 $234.00 $166.99
180 pills $1.33 $351.00 $239.31
270 pills $1.29 $526.50 $347.81
360 pills $1.27 $702.00 $456.30
5 mg
Product name Per Pill Per Pack  
10 pills $4.00 $40.00
20 pills $3.27 $80.00 $65.46
30 pills $3.03 $120.00 $90.92
60 pills $2.79 $240.00 $167.31
90 pills $2.71 $360.00 $243.69
120 pills $2.67 $480.00 $320.08
180 pills $2.63 $720.00 $472.84
270 pills $2.60 $1,080.00 $702.00
10 mg
Product name Per Pill Per Pack  
10 pills $6.26 $62.60
20 pills $4.93 $125.20 $98.69
30 pills $4.49 $187.80 $134.78
60 pills $4.05 $375.60 $243.04
90 pills $3.90 $563.40 $351.30
120 pills $3.83 $751.20 $459.55
180 pills $3.76 $1,126.80 $676.08

Common use

Methotrexate Koçak is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.
Methotrexate Koçak is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.

Dosage and direction

Take exactly as prescribed by your physician. Take Methotrexate Koçak orally with or without food. Do not chew or crush the tablet. To treat rheumatoid arthritis and psoriasis Methotrexate Koçak is taken weekly. Starting dose 7.5 mg of the medication once a week or 2.5 mg each twelve hours three times also once weekly. Treatment of cancer requires individual dosage and treatment only under control of your doctor.

Precautions

Caution should be exercised in the patients with ascites, dehydration, obstructive diseases of the digestive tract, pleural or peritoneal effusion, chronic renal failure, parasitic and infectious diseases of viral, fungal or bacterial origin due to the possible high risk of severe generalized disease development. Methotrexate Koçak toxicity increases in the individuals with herpes simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis (helminthosis caused by threadworm with allergic symptoms at the beginning of the disease), gout (also in history), infection and inflammation of mucosa in the mouth, nausea and vomiting (due to dehydration), stomach and duodenal ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy, asthenia. When Metheotrexate is used to treat cancer cautiousness is need in the patients with aciduria (urine pH less than 7) and inhibited bone marrow hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines should be avoided for 3-12 months since the course of treatment with Methotrexate Koçak was finished. Men and women should use safe contraception as this drug is very toxic for an unborn baby.

Contraindications

This medicine cannot be administered to the patients with hypersensitivity to its components, immune deficiency, pregnant and breastfeeding women. When Methotrexate Koçak is used to treat patents with psoriasis or rheumatic diseases it cannot be used if they also have heavy suppression of bone marrow hematopoiesis, severe kidney or liver failure.

Possible side effect

Methotrexate Koçak is usually well tolerated but some patients may develop mouth sores, stomach upset, and low white blood counts. Methotrexate Koçak is known to be toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done on a regular basis while treatment with this drug. Other adverse reactions may include headache, drowsiness and allergic reactions such as skin rash, itching, dizziness, and hair loss.

Drug interaction

Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take and especially about NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), piroxicam (Feldene) as they increase Methotrexate Koçak toxicity); azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine, sulfinpirazon) requires correction of the dose. Inform your doctor also about chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox), retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin), theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal, Disalcid, Doan's Pills).

Missed dose

Consult your doctor if you miss a dose of this medicine.

Overdose

Contact your doctor immediately if you suspect overdose. Signs of overdose include nausea, vomiting, weakness, paleness, easy bruising or bleeding, mouth sores, black or bloody stools, coughing up blood, vomit similar to coffee grounds, decreased urination or anuria.

Storage

Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Mild to moderate disorders and health abnormalities can bother patients, who misuse or overuse the drug. However, it is not the disadvantage of online shopping, but the inability to follow the recommendations. Those, who take the treatment in accordance with the instructions are likely to prevent abnormalities and serious health impairments. Consult a medical specialist in case you have got any of the following side effects:

More Common

  • Black, tarry stools
  • blood in the urine or stools
  • bloody vomit
  • diarrhea
  • joint pain
  • reddening of the skin
  • sores in the mouth or lips
  • stomach pain
  • swelling of the feet or lower legs
  • Hair loss, temporary
  • loss of appetite
  • nausea or vomiting

Less Common

  • Back pain
  • blurred vision
  • confusion
  • convulsions (seizures)
  • cough or hoarseness
  • dark urine
  • dizziness
  • drowsiness
  • fever or chills
  • headache
  • lower back or side pain
  • painful or difficult urination
  • pinpoint red spots on the skin
  • shortness of breath
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
  • Acne
  • boils on skin
  • pale skin
  • skin rash or itching
Type Small Molecule
Accession Number DB00563  (APRD00353)
Groups Approved
Synonyms
  • 4-amino-10-methylfolic acid
  • 4-amino-N(10)-methylpteroylglutamic acid
  • Amethopterin
  • Methotrexat
  • Méthotrexate
  • Methotrexatum
  • Metotrexato
  • MTX
  • N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
UNII YL5FZ2Y5U1
CAS number 59-05-2
Weight Average: 454.4393
Monoisotopic: 454.171315854
Chemical Formula C20H22N8O5
InChI
InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
IUPAC Name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Protein binding

50% bound to protein, primarily to albumin

Toxicity

Symptoms of overdose include bone marrow suppression and gastrointestinal toxicity. LD50=43mg/kg(orally in rat).

Half life

Low doses (less than 30 mg/m^2): 3 to 10 hours; High doses: 8 to 15 hours.

There is hardly any place in the world we cannot deliver our products to. To ensure the convenience of all our clients, we provide international shipping. With the option of the worldwide delivery, you will be able to receive the purchased medication fast and easily. We also ship to a range of places in Australia, among which are the following cities:

  • Sana'a
  • Ta'izz
  • Al Hudaydah
  • Aden
  • Ibb
  • Dhamar
  • Mukalla
  • Seiyun
  • Zinjibar
  • Sayyan
  • Ash Shihr
  • Sahar
  • Zabid
  • Hajjah
  • Bajil District
  • Dhi as-Sufal
  • Rada'a
  • Socotra
  • Bait al-Faqih
  • al-Marawi'a
  • Yarim
  • Al Bayda'
  • Amran
  • Lahij
  • Abs